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ABOUT

The Cellufine product line consists of chromatography media designed for the purification of proteins, enzymes, and other biomolecules. This media line is based on spherical cellulose beads, which exhibit high chemical stability, high mechanical strength, and inherent biocompatibility. These Cellufine chromatography products are ideally suited for the purification of biopharmaceuticals and food products. And leachables from cellulose-based media are significantly lower than for comparable polymeric beads.
Cellufine chromatography products are appropriate for all chromatographic techniques. Gel Filtration, Ion Exchange, Affinity, and Hydrophobic Interaction chromatography media are available for purification of a broad range of target molecules. In addition, JNC Corp. can provide custom media, such as big beads or special affinity ligands, for use in challenging purification process.

Cellufine chromatography media is
designed for use in
biopharmaceutical manufacture.

Scanning electron microscope (SEM) photo of Cellufine

Typical applications include protein and polysaccharide purification, and endotoxin removal. Cellufine media is used worldwide in chromatographic purification of vaccines, therapeutic enzymes and proteins, and virus concentration/purification.

Cellufine chromatography media is
based on porous,
spherical cellulose bead architecture optimized for large scale biopharmaceutical manufacturing.

Scanning electron microscope (SEM) photograph of Cellufine, spherical and uniform porous particles

JNC pioneered cellulose bead formation technology, providing robust, spherical, porous beads optimized for biopharmaceutical manufacturing. Cellulose based chromatography media can be efficiently packed in deep beds in chromatography columns and can be operated at high linear velocity flow rates with low backpressure.

Scanning electron microscope (SEM) photograph of Cellufine, the surface is fibrous and has porous structure

Flexible modification of the basic cellulose matrix polymer with different ligands facilitates the purification of a broad range of biomolecules.

PRODUCTS

The Product Range of
Cellufine Chromatograpy Media

Cellufine media products are appropriate for all modes of chromatography: Ion Exchange, Affinity, Hydrophobic Interaction, Mix mode and Gel Filtration. The table below lists available standard products. In addition, customized products can be developed by modifying bead size, porosity, and ligand chemistry. Cellufine products are packaged in a variety of container sizes ranging from 10 ml to 10 L. In addition to standard bottles, most products are available in pre-packed mini-column formats with media volumes of 1 to 5 ml. Larger packaging size containers are available on request.

  • Affinity Cellufine resins derivatized with high affinity bio-specific ligands
  • HIC Cellufine resins derivatized with ligands to develop hydrophobic interaction-based separations
  • IEX Cellufine utilizing a wide range of ion exchange ligands
  • Gel filtration Cellufine resins that can be used to separate molecules based on molecular size
  • Mix mode Cellufine resins that contain both ion exchange and hydrophobic ligands
  • Pre-Packed columns available with a wide range of Cellufine resins
  • Empty column hardware for self-packing applications

ADSORPTION

ION EXCHANGE

For initial separation and final polishing of proteins, peptides and enzymes.

DEAE Weak Anion

QA Strong Anion

MAX Q Strong Anion

CM Weak Cation

S Strong Cation

MAX S Strong Cation

AFFINITY

For high specificity separations of a wide range of molecules

Virus & Heparin Binding Proteins, Coagulation Factors

Nucleic acid bunding protein & Nuclease, Histones

Endotoxin removal

Activated Supports

ANTIBODY PUIFICATION

HYDROPHOBIC INTERACTION

For purification of proteins and enzymes based on hydrophobic interactions

MIX MODE

For polishing applications to remove trace levels of contaminants exploiting AEX and hydrophobic interactions

GEL FILTRATION

GEL FILTRATION

For purification of biomolecules and proteins by molecular size

MW-50 - 3,000 kD

For desalting, solvent removal applications, and buffer exchange

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