Successfully developed a porous hydroxyapatite material having high porosity

December 25, 2012

A novel material, a porous hydroxyapatite (HAp) having high porosity has been developed jointly by JNC Corporation (Head office: Chiyoda-ku, Tokyo, President: Michio Morita) and SofSera Corporation (Head office: Shinjuku-ku, Tokyo, President: Kazushige Karl Kawabe). Nanosized particles of HAp which SofSera Corporation developed are used as a raw material. The new product consists of HAp nanofibers whose diameter are several hundred nanometers.

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【Product features】
(1) Features and characteristics
 The novel material has both a high porosity (connecting hole), 85 to 90 % and moderate mechanical strength. And it has a high-specific surface area because of fibrous form. Lower porosity than the above can be obtained with adjusted manufacturing conditions. And the product is changeable its figure such as disk or rod.
(2) Potential applications
 Taking advantages of its characteristics of high biocompatibility, high specific surface area and high porosity, this product is expected to use as cell culture substratum, protein adsorption material, carrier of biologically active agent or chemical catalyst and so on. Further we will develop the product designed for such applications.
(3)Sample product
 SofSera Corporation will start providing the sample products for research use in February 2013.

SEM image      scale: 1mm
 Photo by SofSera

【Backgrounds and achievements】
 Generally synthetic HAp which is a cluster of nanoparticles has difficulty in handling. For example, affinity chromatographic column packed with HAp nanoparticles results in clogging easily. However,the porous HAp material made of nanofiber can be handed easily in many applications without significant decreasing intrinsic features such as high surface area and biocompatibility.Furthermore the porous HAp material shows novel fiber structure and then has a great potential to use in wide range of fields.

【What is Hydroxyapatite (HAp)】
 HAp is basically calcium phosphate with the formula Ca10(PO4)6(OH)2. It is the main component of bones and teeth, and also exists as a mineral. And some methods for the artificial synthesis of HAp are established. HAp is known as having high biocompatibility and has been utilized in a variety of life sciences.